Necroptosis is a regulated necrotic cell death pathway involved in development and disease. Its signaling cascade results in the formation of disulfide bond-dependent amyloid-like polymers of mixed lineage kinase domain-like protein (MLKL), which mediate proinflammatory cell membrane disruption. We screened compound libraries provided by the National Cancer Institute and identified...

中文翻译：

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阻断坏死病的化合物NBC1靶向热激蛋白70，以抑制MLKL聚合和坏死病[生物化学]

坏死性坏死是一种参与发育和疾病的调控坏死性细胞死亡途径。它的信号级联反应导致混合谱系激酶结构域样蛋白（MLKL）的二硫键依赖性淀粉样聚合物形成，介导促炎细胞膜破坏。我们筛选了国家癌症研究所提供的化合物库并确定了...