Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block CRISPR-Cas-mediated genome editing in eukaryotic cells. To identify Acrs capable of inhibiting Staphylococcus aureus Cas9 (SauCas9), an...

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来自葡萄球菌基因组的有效CRISPR-Cas9抑制剂[生物化学]

Anti-CRISPRs（Acrs）是抑制CRISPR-Cas酶RNA引导的DNA靶向活性的小蛋白。Acrs由噬菌体和噬菌体衍生的细菌基因编码，可防止CRISPR介导的对噬菌体感染的抑制，还可以阻止CRISPR-Cas介导的真核细胞基因组编辑。为了鉴定能够抑制金黄色葡萄球菌Cas9（SauCas9）的Acrs，...