Diatom algae can produce bioactive compounds like fucoxanthin (FX) and ecosapentaenoic acid (EPA) which are of high demand in pharmaceutical and nutraceutical industries. Here, the influence of different light regimes in combination with major nutrients on growth, FX and EPA production by marine diatom Thalassiosira weissflogii were investigated. Batch cultures of T. weissflogii were illuminated under blue (BL), red (RL) and white (WL) light at two intensities. BL regime resulted in higher cell density with a specific growth rate of 2.49µ. Lipid productivity and lipid % as dry cell weight (DCW) was considerably higher in BL with EPA productivity of 33.4 mg L⁻¹d⁻¹. Fucoxanthin content as % DCW reached 0.95 (BL), 0.75 (RL) and 0.81 (WL) at mid exponential growth phase. The results further prove the plasticity of diatoms and provide a way for future metabolic engineering of T. weissflogii for potential microalgal bio-refinery for combined EPA and FX production.

硅藻藻可以生产生物活性化合物，如岩藻黄质（FX）和生态木五烯酸（EPA），在制药和营养保健行业中需求量很大。在这里，研究了不同的光照方案与主要养分组合对海洋硅藻Thalassiosira weissflogii的生长，FX和EPA产生的影响。在两个强度的蓝（BL），红（RL）和白（WL）光下照明魏氏锥虫的分批培养物。BL方案导致更高的细胞密度，比生长速率为2.49µ。BL中的脂质生产率和脂质％（以干细胞重量（DCW）计）高得多，EPA生产率为33.4 mg L ^-1 d ^-1。在中等指数生长期，褐藻黄质含量以DCW％计分别达到0.95（BL），0.75（RL）和0.81（WL）。结果进一步证明了硅藻的可塑性，并为魏氏罗非鱼的未来代谢工程化提供了可能的方法，用于潜在的微藻生物精炼厂，用于联合生产EPA和FX。