当前位置: X-MOL 学术Schizophr. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Impaired memory for temporal context in schizophrenia patients with hallucinations and thought disorganisation
Schizophrenia Research ( IF 3.6 ) Pub Date : 2020-06-01 , DOI: 10.1016/j.schres.2020.03.014
Gildas Brébion 1 , Christian Stephan-Otto 1 , Jorge Cuevas-Esteban 2 , Judith Usall 1 , Susana Ochoa 1
Affiliation  

INTRODUCTION Context processing deficiencies have been established in patients with schizophrenia and it has been proposed that these deficiencies are involved in the formation of positive symptoms. METHOD We administered a temporal context discrimination task to 60 schizophrenia patients and 60 healthy individuals. Pictures were presented in two sessions separated by half an hour and the participants were required to remember afterwards whether the pictures had been presented in the first or the second session. RESULTS The number of temporal context errors was significantly increased in the patient group. More specifically, it was highly significantly increased in a subgroup of patients presenting hallucinations, while the patients without hallucinations were equivalent to the healthy individuals. Regression analyses revealed that, independently of memory of the pictures themselves, verbal and visual hallucinations, as well as thought disorganisation, were associated with more temporal context errors. In contrast, affective flattening and anhedonia were associated with fewer of these errors. CONCLUSION Inability to process or remember the temporal context of production of events might be a mechanism underlying both hallucinations and thought disorganisation.

中文翻译:

幻觉和思维混乱的精神分裂症患者对时间上下文的记忆受损

引言 精神分裂症患者存在语境处理缺陷,有人提出这些缺陷与阳性症状的形成有关。方法 我们对 60 名精神分裂症患者和 60 名健康个体进行了时间背景辨别任务。图片分两次展示,间隔半小时,参与者需要记住图片是在第一次展示还是第二次展示。结果 患者组中时间上下文错误的数量显着增加。更具体地说,它在出现幻觉的患者亚组中显着增加,而没有幻觉的患者与健康人相当。回归分析表明,独立于图片本身的记忆,语言和视觉幻觉以及思维混乱与更多的时间上下文错误有关。相比之下,情感扁平化和快感缺乏与这些错误较少相关。结论 无法处理或记住事件产生的时间背景可能是幻觉和思维混乱的潜在机制。
更新日期:2020-06-01
down
wechat
bug