Journal of Organometallic Chemistry ( IF 2.1 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.jorganchem.2020.121246 Mohan Rao Kollipara , Lathewdeipor Shadap , Venkanna Banothu , Nipanshu Agarwal , Krishna Mohan Poluri , Werner Kaminsky
Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N∩N bonded complexes. The biological studies of these complexes such as antibacterial activity studies (against Gram-positive and Gram-negative bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). Whilst for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity.
中文翻译:
钌,铑和铱的芴酮席夫碱衍生物配合物表现出有效的抗菌活性和DNA结合亲和力
与9-芴酮衍生物配体L1,L2和L3反应的金属前体[(亚芳基)MCl 2 ] 2(亚芳基= 对-cymene,Cp *; M = Ru,Rh和Ir)导致单核双齿阳离子N的形成∩N键合配合物。这些复合物的诸如抗菌活性的研究(对革兰阳性和革兰氏阴性细菌)的生物的研究揭示了与络合物显著抗菌活性4,7和9具有最高的活性效力(体外)。在进行DNA结合研究时,结果显示复合物4和5 在添加SM-DNA时,它们的光谱特征发生了显着变化,因此表明这些复合物以显着的亲和力与DNA结合。