Many nanomedicine approaches are struggling to reach high enough effectiveness in delivery if applied systemically. The perspective is sought to explore the clinical practices currently used for localized treatment. In this study, we combine in vivo targeting of carriers sensitive to the external magnetic field with clinically used endovascular delivery to specific site. Fluorescent micron-size capsules made of biodegradable polymers and containing magnetite nanoparticles incorporated in the capsule wall were explored in vivo using Near-Infrared Fluorescence Live Imaging for Real-Time. Comparison of systemic (intravenous) and directed (intra-arterial) administration of the magnetic microcapsule targeting in the hindpaw vessels demonstrated that using femoral artery injection in combination with magnetic field exposure is 4 times more efficient than tail vein injection. Thus, endovascular targeting significantly improves the capabilities of nanoengineered drug delivery systems reducing the systemic side effects of therapy.

如果系统地应用，许多纳米医学方法都在努力达到足够高的递送效率。寻求透视图以探索当前用于局部治疗的临床实践。在这项研究中，我们将对外部磁场敏感的载体的体内靶向与临床使用的血管内递送到特定部位相结合。在体内探索了由可生物降解的聚合物制成并包含掺入胶囊壁中的磁铁矿纳米粒子的微米级荧光胶囊使用近红外荧光实时成像进行实时分析。比较后爪血管中靶向磁性微胶囊的全身性（静脉内）和定向（动脉内）给药，结果表明，将股动脉注射与磁场暴露相结合使用的效率比尾静脉注射高4倍。因此，血管内靶向显着改善了纳米工程药物递送系统的能力，从而降低了治疗的全身性副作用。