Non-lamellar lyotropic liquid crystalline nanocarriers such as hexosomes and cubosomes are relatively unexplored lipid-based nanoparticles in nanomedicine that can be specifically formulated to match specific medical applications, thus exploiting the majority of the possible routes of administrations. A growing number of papers demonstrate intriguing features that make them good candidates as nanocarriers for therapeutically active molecules or imaging probes. Yet, important aspects, including pharmacokinetics, hemocompatibility, toxicity, and delivery properties, are not completely clarified, so that their full potential as nanomedicines remains to be assessed.

This article reviews recent advances in the field and suggests possible new routes forward.

非层状溶致液晶纳米载体（例如六体和立方体）是纳米医学中相对未开发的基于脂质的纳米颗粒，可以根据特定的医学应用进行特殊配制，从而利用了大多数可能的给药途径。越来越多的论文证明了吸引人的功能，使其成为治疗活性分子或成像探针的纳米载体的良好候选者。然而，包括药代动力学，血液相容性，毒性和递送特性在内的重要方面尚未完全阐明，因此它们作为纳米药物的全部潜力仍有待评估。

本文回顾了该领域的最新进展，并提出了可能的新路线。