Quantitative modeling of the interplay between synthetic gene circuits and host physiology: experiments, results, and prospects.,Current Opinion in Microbiology

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Quantitative modeling of the interplay between synthetic gene circuits and host physiology: experiments, results, and prospects.
Current Opinion in Microbiology ( IF 5.9 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.mib.2020.02.008
Ismael Sánchez-Osorio ₁ , Carlos Andrés Hernández-Martínez ₁ , Agustino Martínez-Antonio ₁

Affiliation

A primary goal of synthetic biology is to develop gene circuits that perform their intended functions despite variations in the growth conditions. However, this has turned out to be more complicated than it originally seemed because there is a complex interplay between the operation of synthetic gene circuits and the global physiology of host cells. Mathematical models provide an avenue to disentangle the intricacies of this phenomenon and guide the design of synthetic circuits that robustly perform in a variety of conditions. In this work, we review quantitative modeling approaches that have been used to rationalize and predict experimental observations resulting from circuit-to-circuit and circuit-host interactions in bacteria.

中文翻译：

合成基因回路与宿主生理之间相互作用的定量建模：实验，结果和前景。

合成生物学的主要目标是开发基因回路，即使生长条件发生变化，它们也可以执行其预期功能。然而，事实证明，这比最初看起来要复杂得多，因为合成基因电路的操作与宿主细胞的整体生理之间存在复杂的相互作用。数学模型提供了一种途径，可以弄清这种现象的复杂性，并指导在各种条件下都能稳定工作的合成电路的设计。在这项工作中，我们回顾了定量建模方法，这些方法已用于合理化和预测细菌中电路与电路以及电路与主机之间的相互作用所产生的实验观察结果。

更新日期：2020-03-26

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