Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Inflammation in myocardial injury- Stem cells as potential immunomodulators for myocardial regeneration and restoration.
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.lfs.2020.117582 Sajini Vadivel 1 , Preethi Vincent 1 , Saravanan Sekaran 1 , Senthil Visaga Ambi 1 , Shibi Muralidar 1 , Vimalraj Selvaraj 2 , Balamurugan Palaniappan 1 , Diraviyam Thirumalai 1
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.lfs.2020.117582 Sajini Vadivel 1 , Preethi Vincent 1 , Saravanan Sekaran 1 , Senthil Visaga Ambi 1 , Shibi Muralidar 1 , Vimalraj Selvaraj 2 , Balamurugan Palaniappan 1 , Diraviyam Thirumalai 1
Affiliation
|
The ineffective immunosuppressant's and targeted strategies to neutralize inflammatory mediators have worsened the scenario of heart failure and have opened many questions for debate. Stem cell therapy has proven to be a promising approach for treating heart following myocardial infarction (MI). Adult stem cells, induced pluripotent stem cells and embryonic stem cells are possible cell types and have successfully shown to regenerate damaged myocardial tissue in pre-clinical and clinical studies. Current implications of using mesenchymal stem cells (MSCs) owing to their immunomodulatory functions and paracrine effects could serve as an effective alternative treatment option for rejuvenating the heart post MI. The major setback associated with the use of MSCs is reduced cell retention, engraftment and decreased effectiveness. With a few reports on understanding the role of inflammation and its dual effects on the structure and function of heart, this review focuses on these missing insights and further exemplifies the role of MSCs as an alternative therapy in treating the pathological consequences in myocardial infarction (MI).
中文翻译：
心肌损伤中的炎症-干细胞是心肌再生和修复的潜在免疫调节剂。
无效的免疫抑制剂和中和炎性介质的针对性策略使心力衰竭的情况恶化，并引发了许多争论的问题。干细胞疗法已被证明是治疗心肌梗塞（MI）后心脏的一种有前途的方法。成人干细胞，诱导性多能干细胞和胚胎干细胞是可能的细胞类型，并且在临床前和临床研究中已成功显示出可以再生受损的心肌组织。由于间充质干细胞（MSC）的免疫调节功能和旁分泌作用，目前的意义可能是将心肌梗死后的心脏恢复活力的有效替代疗法。与使用MSC相关的主要障碍是细胞滞留，移入和有效性降低。
更新日期：2020-03-26
中文翻译：
心肌损伤中的炎症-干细胞是心肌再生和修复的潜在免疫调节剂。
无效的免疫抑制剂和中和炎性介质的针对性策略使心力衰竭的情况恶化，并引发了许多争论的问题。干细胞疗法已被证明是治疗心肌梗塞（MI）后心脏的一种有前途的方法。成人干细胞，诱导性多能干细胞和胚胎干细胞是可能的细胞类型，并且在临床前和临床研究中已成功显示出可以再生受损的心肌组织。由于间充质干细胞（MSC）的免疫调节功能和旁分泌作用，目前的意义可能是将心肌梗死后的心脏恢复活力的有效替代疗法。与使用MSC相关的主要障碍是细胞滞留，移入和有效性降低。
京公网安备 11010802027423号