Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone.,Bioorganic & Medicinal Chemistry

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Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone.
Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.bmc.2020.115463
Christian Bailly ₁ , Paul-Emile Hecquet ₂ , Mostafa Kouach ₂ , Xavier Thuru ₃ , Jean-François Goossens ₂

Affiliation

1-Phenyl-3-methyl-5-pyrazolone is a reagent, known as PMP, used to derivatize monosaccharides for the study of polysaccharides composition and structure, and for the dosage of carbohydrates in complex media. The same molecule is also known as edaravone, a drug approved for the treatment of stroke and amyotrophic lateral sclerosis. It is also a reactive molecule susceptible to form stable adducts with aromatic aldehydes, such as formylpterin and vanillin. In addition, the molecule serves as a scaffold to design of edaravone analogs and drug conjugates, with various pharmacological properties (antioxidant, anticancer, antiviral). We have analyzed the multiple usages of PMP/edaravone to highlight the reactivity of the molecule and its wide range of applications. This phenyl-pyrazolone compound, considered by many as a biochemical reagent and by other as a clinically useful drug, has not yet revealed the full extent of its capacities and benefits.

中文翻译：

1-苯基-3-甲基-5-吡唑啉酮（PMP）（也称为依达拉奉）的化学反应性和用途。

1-苯基-3-甲基-5-吡唑啉酮是一种试剂，称为PMP，用于衍生单糖，用于研究多糖的组成和结构以及在复杂介质中碳水化合物的剂量。同一分子也被称为依达拉奉，它是一种被批准用于治疗中风和肌萎缩性侧索硬化的药物。它也是易与芳香醛如甲酰蝶呤和香兰素形成稳定加合物的反应性分子。此外，该分子还充当依达拉奉类似物和药物结合物设计的支架，具有多种药理特性（抗氧化剂，抗癌剂，抗病毒剂）。我们分析了PMP /依达拉奉的多种用法，以突出分子的反应性及其广泛的应用范围。这种苯基吡唑啉酮化合物，

更新日期：2020-04-20

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