Calcium pyrophosphate (CPP) deposition disease (CPPD) is a prevalent condition characterised by the presence of CPP crystals in articular tissues, especially hyaline cartilage and fibrocartilage. It is most frequently idiopathic, but CPPD may also be associated with other metabolic disorders, such as primary hyperparathyroidism, hereditary hemochromatosis or hypomagnesemia (eg, in a context of Gitelman’s disease).1 Some mutations, such as in ANKH , have also been described in familial forms of the disease.2 CPPD is a cause of acute or chronic inflammatory arthritis. The management of CPP crystal–induced arthritis has been extrapolated from that of gout flares and includes colchicine, non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids.1 In cases of failure of or contraindications to these drugs, case series suggested that the interleukin 1 (IL-1) inhibitor anakinra was an alternative, especially in acute CPP arthritis.3 However, IL-1 inhibitors may be ineffective or induce …

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托珠单抗治疗有症状的焦磷酸钙沉积病：一项初步研究

焦磷酸钙 (CPP) 沉积病 (CPPD) 是一种普遍存在的疾病，其特征是关节组织中存在 CPP 晶体，尤其是透明软骨和纤维软骨。它最常见是特发性的，但 CPPD 也可能与其他代谢疾病有关，例如原发性甲状旁腺功能亢进症、遗传性血色病或低镁血症（例如，在 Gitelman 病的背景下）。 1 一些突变，例如 ANKH，也已被描述在该疾病的家族形式中。2 CPPD 是急性或慢性炎症性关节炎的原因。CPP 晶体诱发的关节炎的治疗是从痛风发作的治疗中推断出来的，包括秋水仙碱、非甾体抗炎药 (NSAID) 或皮质类固醇。 1 如果这些药物无效或有禁忌症，