Response to: ‘Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies’ by Yang et al,Annals of the Rheumatic Diseases

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Response to: ‘Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies’ by Yang et al
Annals of the Rheumatic Diseases ( IF 20.3 ) Pub Date : 2022-03-01 , DOI: 10.1136/annrheumdis-2020-217106
Lionel Spielmann ₁ , Benoit Nespola ₂ , Alain Meyer _{3,

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Affiliation

We would like to thank Yang et al 1 for their rewarding comment on our work, in which we report that patients harbouring anti-Ku autoantibodies with elevated serum levels of creatine kinase (elevated CK) are at risk of interstitial lung disease (ILD), whereas anti-Ku patients with anti-dsDNA are frequently affected by systemic lupus erythematosus and are at risk of glomerulonephritis.2 Yang et al retrospectively investigated 1214 patients with myositis (defined on Bohan and Peter criteria) in a single Chinese centre. Twenty-one patients (1.7%) had anti-Ku antibodies, defined as a fine speckled pattern seen at immunofluorescence, together with positive commercial assay results. In accordance with …

更新日期：2022-02-14

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