OBJECTIVE To identify sleep duration trajectories from early to middle adulthood and their associations with incident type 2 diabetes. RESEARCH DESIGN AND METHODS Using a group-based modeling approach, we identified sleep duration trajectories based on sleep duration in ages 20-25, 26-35, 36-45, and 46+ years, which were retrospectively assessed in 2009 among 60,068 women from the Nurses' Health Study II (median age 54.9 years) who were free of diabetes, cardiovascular disease, and cancer. We investigated the prospective associations between sleep duration trajectories and diabetes risk (2009-2017) using multivariable Cox proportional hazards models. RESULTS We documented 1,797 incident diabetes cases over a median follow-up of 7.8 years (442,437 person-years). Six sleep duration trajectories were identified: persistent 5-, 6-, 7-, or 8-h sleep duration and increased or decreased sleep duration. After multivariable adjustment for diabetes risk factors, compared with the persistent 7-h sleep duration group, the hazard ratio was 1.43 (95% CI 1.10, 1.84) for the 5-h group, 1.17 (1.04, 1.33) for the 6-h group, 0.96 (0.84, 1.10) for the 8-h group, 1.33 (1.09, 1.61) for the increased sleep duration group, and 1.32 (1.10, 1.59) for the decreased sleep duration group. Additional adjustment for time-updated comorbidities and BMI attenuated these associations, although a significantly higher risk remained in the decreased sleep duration group (1.24 [1.03, 1.50]). CONCLUSIONS Persistent short sleep duration or changes in sleep duration from early to middle adulthood were associated with higher risk of type 2 diabetes in later life. These associations were weaker after obesity and metabolic comorbidities were accounted for.

中文翻译：

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成年早期至中期的睡眠时间模式以及女性随后发生2型糖尿病的风险。

目的确定成年早期至中期的睡眠时间轨迹及其与2型糖尿病的关联。研究设计和方法使用基于组的建模方法，我们基于20-25岁，26-35岁，36-45岁和46岁以上的睡眠时间确定了睡眠时间轨迹，这些轨迹于2009年在60,068名来自没有糖尿病，心血管疾病和癌症的护士健康研究II（中位年龄54.9岁）。我们使用多变量Cox比例风险模型调查了睡眠时间轨迹与糖尿病风险（2009-2017）之间的前瞻性关联。结果我们记录了1797例糖尿病患者，平均随访7.8年（442,437人年）。确定了六种睡眠持续时间轨迹：持续性5、6、7，或8小时睡眠时间，并增加或减少睡眠时间。在对糖尿病危险因素进行多变量调整后，与持续7小时睡眠持续时间组相比，5小时组的危险比是1.43（95％CI 1.10，1.84），6小时的危险比是1.17（1.04，1.33） 8小时组0.96（0.84，1.10），睡眠时间延长组1.33（1.09，1.61），睡眠时间减少组1.32（1.10，1.59）。对时间更新的合并症和BMI进行额外的调整可以减弱这些关联，尽管睡眠时间减少组中的风险仍然明显较高（1.24 [1.03，1.50]）。结论持续的短暂睡眠时间或成年早期至中期的睡眠时间变化与以后生活中2型糖尿病的较高风险有关。