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Drug Distribution in Living Cells via Label-Free Molecular Fingerprint.
Journal of Medicinal Chemistry ( IF 7.3 ) Pub Date : 2020-03-25 , DOI: 10.1021/acs.jmedchem.0c00392
Samir F El-Mashtoly 1
Affiliation  

A new application of stimulated Raman scattering (SRS) uses the benefit of a label-free molecular fingerprint to image the uptake and distribution of an alkyne-based drug in living cells. This method delivers information on cellular molecular composition and drug–cell interaction, showing the potential of SRS in drug development.

中文翻译:

通过无标记分子指纹在活细胞中进行药物分配。

受激拉曼散射(SRS)的一项新应用利用了无标记分子指纹的优势来成像基于炔烃的药物在活细胞中的吸收和分布。该方法提供有关细胞分子组成和药物-细胞相互作用的信息,显示了SRS在药物开发中的潜力。
更新日期:2020-03-26
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