Acetate: An Alcohol Metabolite as a Growth Promoter of Pathological Crystallization of Gout,Crystal Growth & Design

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Acetate: An Alcohol Metabolite as a Growth Promoter of Pathological Crystallization of Gout
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2020-03-25 , DOI: 10.1021/acs.cgd.9b01518
Yonghai Liu ₁ , Rong Cheng ₁ , Chunyan Ou ₁ , Xingde Zhang ₁ , Tingming Fu ₁

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In many instances, it has been reported that growth inhibitors containing carboxyl groups can potentially interact with metal cations on a crystal surface to suppress the growth of crystallization. There are fewer reports about modifiers which operate as growth promoters, whereby modifier–crystal interactions accelerate the growth of crystallization. Here, we present that the acetate (ACE), as an alcohol metabolite, is able to obviously promote the growth of the pathological crystallization of gout not only under model physiological conditions but also in the Na⁺, K⁺, Ca²⁺, and hyaluronate^– ion-containing solutions. This approach could help our understanding of the association between alcohol consumption and increased risk of recurrent gout attacks, since the “triggers”, that is, crystallization factors immediately before gout attacks, still remain speculative. Finally, a possible explanation for the effect of ACE on monosodium urate monohydrate (MSUM) growth is proposed on the basis of quantum chemical calculations (QCC).

中文翻译：

醋酸盐：一种酒精代谢物，是痛风病的结晶结晶的生长促进剂

在许多情况下，据报道含羧基的生长抑制剂可以潜在地与晶体表面上的金属阳离子相互作用以抑制结晶的生长。关于作为生长促进剂的改性剂的报道较少，因此改性剂与晶体的相互作用加速了结晶的生长。在这里，我们提出乙酸盐（ACE）作为一种醇代谢物，不仅能够在模型生理条件下而且在Na ⁺，K ⁺，Ca ²⁺和Na ^+中显着促进痛风的病理性结晶的生长。透明质酸盐^–含离子溶液。这种方法可以帮助我们了解饮酒与复发性痛风发作风险增加之间的关系，因为“触发因素”（即痛风发作之前的结晶因素）仍然是推测性的。最后，基于量子化学计算（QCC），提出了ACE对尿酸一钠一水合物（MSUM）生长的影响的可能解释。

更新日期：2020-03-25

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