Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan,ACS Applied Nano Materials

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Urchin-Like Chiral Metal–Organic Framework/Reduced Graphene Oxide Nanocomposite for Enantioselective Discrimination of d/l-Tryptophan
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2020-03-25 , DOI: 10.1021/acsanm.0c00389
Jialei Guo ₁ , Xiaofeng Wei ₁ , Huiting Lian ₁ , Lishang Li ₁ , Xiangying Sun ₁ , Bin Liu ₁

Affiliation

An urchin-like chiral metal–organic framework/reduced graphene oxide (urchin-CMOF/rGO) nanocomposite was developed as the electrochemical sensing interface for robust, efficient, and high-selective discrimination of tryptophan (Trp) enantiomers. An urchin-CMOF/rGO nanocomposite was elaborately integrated to combine the amplification of electrical conduction by rGO and the enantioselectivity by asymmetric CMOF. On the basis of this novel nanocomposite-mediated sensor, chiral recognition of d/l-Trp was successfully achieved by the differential potential ratiometric method. Different percentages of Trp racemic mixtures were determined in a good linear relationship with specific peak potentials, which effectively detours the nonspecific signal of concomitant interference from most current-based voltammetries. Even in the complex human cerebrospinal fluid, the simulative ratiometric results of Trp-spiked samples were accurately detected with low false negatives. Additionally, diverse CMOF-regulated hybrid materials have great potential for chiral recognition in pharmaceutical monitoring and biochemical analysis.

中文翻译：

Urchin样手性金属-有机骨架/还原的氧化石墨烯纳米复合材料，用于对d / l-色氨酸的对映选择性鉴别

开发了一种类似海胆的手性金属-有机骨架/氧化石墨烯（urchin-CMOF / rGO）纳米复合材料，作为色氨酸（Trp）对映异构体的稳健，高效和高选择性鉴别的电化学传感界面。精心整合了urchin-CMOF / rGO纳米复合材料，以结合rGO的电传导放大和不对称CMOF的对映选择性。在这种新型的纳米复合物介导的传感器的基础上，d / l的手性识别-Trp是通过差分电势比例法成功实现的。确定了不同百分比的Trp外消旋混合物与特定峰电位的良好线性关系，这有效地绕开了来自大多数基于电流的伏安法伴随干扰的非特异性信号。即使在复杂的人脑脊液中，也可以准确地检测出Trp掺入样品的模拟比例结果，且假阴性率低。此外，多种CMOF调控的杂化材料在药物监测和生化分析中具有巨大的手性识别潜力。

更新日期：2020-03-25

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