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One-Pot Amberlyst 15-Controlled Cyclocondensation of Piperidines and Arylaldehydes: Synthesis of 3,5-Diarylmethylpyridines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-03-25 , DOI: 10.1021/acs.joc.9b03315
Meng-Yang Chang, Yu-Lin Tsai

Amberlyst 15-controlled one-pot easy-operational intermolecular cyclocondensation of substituted piperidines with arylaldehydes provides diversified 3,5-diarylmethylpyridines in high to excellent yields under refluxing toluene conditions. The uses of various acidic solid supports and reaction solvents are investigated for facile and efficient transformation. A plausible mechanism has been proposed.

中文翻译:

一锅琥珀酸酯15控制的哌啶和芳醛的环缩合反应:3,5-二芳基甲基吡啶的合成

在芳基醛回流下,Amberlyst 15受控的一锅式易操作的哌啶与芳醛的分子间环缩合反应提供了多样化的3,5-二芳基甲基吡啶。研究了各种酸性固体载体和反应溶剂的使用,以实现简便高效的转化。已经提出了一种合理的机制。
更新日期:2020-04-24
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