Facile and Efficient Synthesis of Tri‐ and Tetrasubstituted 7‐Azabenzofuran Derivatives,Asian Journal of Organic Chemistry

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Facile and Efficient Synthesis of Tri‐ and Tetrasubstituted 7‐Azabenzofuran Derivatives
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-04-06 , DOI: 10.1002/ajoc.202000131
Chunsheng Fu ₁ , Gaoyu Li ₂ , Meng Shen ₂ , Longxia Zhang ₁ , Peng Yu ₂ , Dong Wang ₂

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A facile synthetic protocol for a series of tri‐ and tetrasubstituted 7‐azabenzofuran derivatives has been designed and successfully executed. The usefulness of this protocol is exemplified by the efficient synthesis of a potent HCV NS5B polymerase inhibitor. Compared to the known synthesis, the overall yield has been increased by six times. Those harmful and cost‐effective synthetic steps have been decreased, including reactions requiring the use of halogenating reagents, precious metals, high temperature or high‐pressure operation.

中文翻译：

高效合成三和四取代的7-氮杂苯并呋喃衍生物

已经设计并成功执行了一系列三和四取代的7-氮杂苯并呋喃衍生物的简便合成方案。有效合成有效的HCV NS5B聚合酶抑制剂可举例说明该方案的实用性。与已知的合成方法相比，总产率提高了六倍。减少了那些有害且具有成本效益的合成步骤，包括需要使用卤化试剂，贵金属，高温或高压操作的反应。

更新日期：2020-04-06

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