Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid,Electroanalysis

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Synthesis of Zinc Tetraaminophthalocyanine Functionalized Graphene Nanosheets as an Enhanced Material for Sensitive Electrochemical Determination of Uric Acid
Electroanalysis ( IF 2.7 ) Pub Date : 2020-03-05 , DOI: 10.1002/elan.201900748
Yan‐mei Shi ₁ , Lin Mei ₂ , Jun‐xia Zhang ₁ , Kai Hu ₁ , Xi Zhang ₁ , Zhu‐zhu Li ₂ , Ming‐san Miao ₁ , Xiu‐min Li ₃

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A new electrochemical sensor material has been fabricated via the non‐covalent functionalization of reduced graphene oxide (rGO) and soluble tetramino zincphthalocyanines (ZnPc‐NH₂). Immobilization of uricase onto the synthesized nanohybrids can evidently improve the electrocatalytic activity and selectivity. The obtained composite membrane possesses a great enhancement of electron transfer rate and excellent synergistic electrocatalytic effect toward uric acid (UA) oxidation under the working potential at 0.620 V vs. Ag/AgCl with a scan rate of 0.125 V/s. The effects of the experimental parameters on the electrochemical oxidation responses of UA were investigated and optimized in detail. Under the optimized conditions, the peak currents were proportional to the UA concentration in a range from 0.5 to 100 μmol/L with detection limit of 0.15 μmol/L. Moreover, the developed sensor was applied for UA determination in human urine samples with high accuracy and satisfactory recovery, which is envisioned to have promising applications in monitoring UA in clinical research.

中文翻译：

锌四氨基酞菁官能化的石墨烯纳米片的合成作为增强材料用于尿酸的灵敏电化学测定

通过还原的氧化石墨烯（rGO）和可溶性四氨基锌酞菁（ZnPc-NH ₂）的非共价官能化制备了一种新的电化学传感器材料）。将尿酸酶固定在合成的纳米杂化物上可以明显改善电催化活性和选择性。所获得的复合膜在0.620V vs.Ag/AgCl的工作电位下以0.125V / s的扫描速率具有极大的电子传递速率提高和对尿酸（UA）氧化的优异的协同电催化作用。研究并优化了实验参数对UA电化学氧化反应的影响。在最佳条件下，峰值电流与UA浓度成正比，范围为0.5至100μmol/ L，检出限为0.15μmol/ L。此外，开发的传感器可用于人类尿液样品中的UA测定，具有很高的准确度和令人满意的回收率，

更新日期：2020-03-05

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