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A Simple, Cost‐effective, and Environmentally Friendly Method for Determination of Ciprofloxacin in Drugs and Urine Samples Based on Electrogenerated Chemiluminescence
Electroanalysis ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/elan.201900355 Daniele Pavão e Pavão 1 , Chirlene Nascimento Botelho 1 , Ridvan Nunes Fernandes 1 , Clenilton Costa dos Santos 2 , Flavio Santos Damos 1 , Rita Cássia Silva Luz 1
Electroanalysis ( IF 2.7 ) Pub Date : 2020-03-03 , DOI: 10.1002/elan.201900355 Daniele Pavão e Pavão 1 , Chirlene Nascimento Botelho 1 , Ridvan Nunes Fernandes 1 , Clenilton Costa dos Santos 2 , Flavio Santos Damos 1 , Rita Cássia Silva Luz 1
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Ciprofloxacin is an antibiotic that belongs to the class of drugs known as quinolones and it is frequently used to treat a variety of bacterial infections. The present work aims the development of a simple, cost‐effective, and environmentally friendly method for the determination of ciprofloxacin in drugs and artificial urine samples due to the high importance of this antibiotic for the human health. The proposed method is based on the electrogenerated chemiluminescence (ECL) resulting from the reaction between the ciprofloxacin and the tris(2,2′‐bipyridyl)ruthenium(II) complex. This method exploits a screen‐printed carbon electrode positioned in an ECL cell with capacity to 50 μL of electrolytic solution. The ECL intensity was monitored with the aid of a photodiode. The ECL signal was simultaneously registered to the voltammetric measurements. Under optimized experimental conditions, the ECL method presented a linear response range for ciprofloxacin between 0.5 and 500 μmol L−1 (or 0.0005 and 0.5 mmol L−1). The proposed method presented a detection limit of 0.5 μmol L−1 and it was successfully applied for the ciprofloxacin determination in drugs and artificial urine samples, with good accuracy and precision.
中文翻译：
一种基于电化学发光法测定药物和尿液样品中环丙沙星的简便，经济高效且环境友好的方法
环丙沙星是一种属于喹诺酮类药物的抗生素，通常用于治疗多种细菌感染。由于该抗生素对人类健康的高度重要性，本工作旨在开发一种测定药物和人工尿液样品中环丙沙星的简便，经济高效且环境友好的方法。所提出的方法基于环丙沙星与三（2,2'-联吡啶基）钌（II）络合物之间反应产生的电化学发光（ECL）。该方法利用了位于ECL电池中的丝网印刷碳电极，该电极的容量为50μL电解液。借助于光电二极管监测ECL强度。ECL信号同时记录到伏安测量中。-1（或0.0005和0.5 mmol L -1）。该方法的检出限为0.5μmolL -1，成功地用于药物和人工尿液中环丙沙星的测定，准确度和精密度高。
更新日期：2020-03-03
中文翻译：
一种基于电化学发光法测定药物和尿液样品中环丙沙星的简便，经济高效且环境友好的方法
环丙沙星是一种属于喹诺酮类药物的抗生素，通常用于治疗多种细菌感染。由于该抗生素对人类健康的高度重要性，本工作旨在开发一种测定药物和人工尿液样品中环丙沙星的简便，经济高效且环境友好的方法。所提出的方法基于环丙沙星与三（2,2'-联吡啶基）钌（II）络合物之间反应产生的电化学发光（ECL）。该方法利用了位于ECL电池中的丝网印刷碳电极，该电极的容量为50μL电解液。借助于光电二极管监测ECL强度。ECL信号同时记录到伏安测量中。-1（或0.0005和0.5 mmol L -1）。该方法的检出限为0.5μmolL -1，成功地用于药物和人工尿液中环丙沙星的测定，准确度和精密度高。
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