Synthesis and Biological Evaluation of Quinoline‐Based Novel Aurones,ChemistrySelect

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Synthesis and Biological Evaluation of Quinoline‐Based Novel Aurones
ChemistrySelect ( IF 1.9 ) Pub Date : 2020-03-24 , DOI: 10.1002/slct.201904912
Gourav Kumar ₁ , Ekta Lathwal ₁ , Bhavna Saroha ₁ , Sanjeev Kumar ₁ , Suresh Kumar ₁ , Nar Singh Chauhan ₂ , Tarun Kumar ₂

Affiliation

A new series of quinoline based aurones 7(a–n) has been synthesized and evaluated for their antibacterial, antifungal and antiquorum sensing activities. These novel aurones have been prepared directly from 2‐chloro‐1‐(2,4‐dihydroxyphenyl)ethan‐1‐one in one pot, by reacting it with differently substituted 2‐chloroquinoline‐3‐carbaldehydes using activated barium hydroxide under solvent free grinding conditions. Structures of these novel aurones are in agreement with their IR, ¹H‐NMR, ¹³C‐NMR and HRMS data. Some of these compounds have attributed a significant antiquorum sensing activity.

中文翻译：

喹啉基新型金酮的合成与生物学评价

已经合成了一系列新的基于喹啉的金刚烷7（a–n），并对其抗菌，抗真菌和抗群体感应活性进行了评估。这些新型的光环化合物是由2-氯-1-（2,4-二羟基苯基）乙-1-酮直接在一个锅中制备的，方法是在无溶剂的情况下，使用活化的氢氧化钡使其与不同取代的2-氯喹啉-3-甲醛反应研磨条件。这些新型金氧烷的结构与其IR，¹ H-NMR，¹³ C-NMR和HRMS数据一致。这些化合物中的一些归因于显着的抗群体感应活性。

更新日期：2020-03-24

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