Biocompatible green tea extract‐stabilised zinc nanoparticles encapsulated by poly(butyl‐2‐cyanoacrylate) with control release profile and antioxidative capacity,International Journal of Food Science & Technology

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Biocompatible green tea extract‐stabilised zinc nanoparticles encapsulated by poly(butyl‐2‐cyanoacrylate) with control release profile and antioxidative capacity
International Journal of Food Science & Technology ( IF 2.6 ) Pub Date : 2020-03-22 , DOI: 10.1111/ijfs.14563
Jing‐Jing Yao _{1,

2} , Peng Zhang ₁ , Zhou‐Ping Fu ₁ , Zhong‐Wen Xie ₁ , Guan‐Hu Bao ₁

Affiliation

Green tea extract‐stabilised Zn nanoparticles (GT‐Zn NPs) encapsulated by poly(butyl‐2‐cyanoacrylate) (PBCA@GT‐Zn NPs) were developed for control release of Zn. The crucial parameters, concentrations of GT‐Zn NPs and the monomer n‐butyl‐2‐cyanoacrylate (BCA), which affected the size, polydispersity indexes (PDI) and encapsulation efficiency (EE %), were evaluated to achieve the smaller size, higher EE (%) and stably and uniformly dispersed NPs. The optimised PBCA@GT‐Zn NPs with <100 nm diameter (46.38 ± 3.46 by SEM, 86.91 ± 3.66 by DLS), PDI (0.159 ± 0.042), zeta potential (−20.56 ± 2.53 mV) and EE (89.31 ± 1.09 %) were obtained. In vitro release of Zn ions was conducted at pH 7.4, showing that Zn from the self‐made tablets and lyophilised PBCA@GT‐Zn NPs is released significantly slower than that of GT‐Zn NPs. Additionally, the PBCA@GT‐Zn NP tablets are pH‐responsive, non‐toxic and antioxidative, suggesting that they could be used as safe food material or drug carriers, contributing to relieve Zn deficiency.

中文翻译：

具有生物相容性的绿茶提取物稳定的锌纳米颗粒，由聚（2-氰基丙烯酸丁酯）封装，具有控制释放特性和抗氧化能力

开发了由聚（2-氰基丙烯酸丁酯）（PBCA @ GT-Zn NPs）封装的绿茶提取物稳定的锌纳米颗粒（GT-Zn NPs），用于控制锌的释放。评估了影响尺寸，关键性参数，多分散指数（PDI）和包封效率（EE％）的关键参数，GT-Zn NPs浓度和单体n-2-氰基丙烯酸正丁酯（BCA），以达到更小的尺寸；较高的EE（％）和稳定且均匀分散的NP。经过优化的PBCA @ GT‐Zn NP，直径小于100 nm（SEM的46.38±3.46，DLS的86.91±3.66），PDI（0.159±0.042），ζ电位（−20.56±2.53 mV）和EE（89.31±1.09％）。体外Zn离子的释放是在pH 7.4下进行的，这表明自制片剂和冻干的PBCA @ GT-Zn NPs中的Zn释放速度明显慢于GT-Zn NPs。此外，PBCA @ GT‐Zn NP片剂具有pH响应，无毒和抗氧化作用，表明它们可用作安全的食品原料或药物载体，有助于缓解锌缺乏症。

更新日期：2020-03-22

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