Biology and biochemistry students must learn to visualize and comprehend the complex three‐dimensional (3D) structures of macromolecules such as proteins or DNA. However, most tools available for teaching biomolecular structures typically operate in two dimensions. Here, we present protocols and pedagogical approaches for using immersive augmented reality (AR) visors, specifically the Microsoft HoloLens, to reinforce learning with large scale 3D holographic structures. We developed a novel workflow to render vividly colored custom biomolecules in AR visors. In addition, we developed AR exercises to review concepts relevant to protein or DNA structure and then implemented the exercises in four different biology and biochemistry courses. Surveys showed that students reported greater interest in biomolecular structures after the exercise. We also highlight some of the advantages and disadvantages of the software and hardware of this upcoming technology.

中文翻译：

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一个探索的想法：使用增强现实来教授三维生物分子结构

生物和生物化学学生必须学习可视化和理解大分子（如蛋白质或 DNA）的复杂三维 (3D) 结构。然而，大多数可用于教授生物分子结构的工具通常以二维方式运行。在这里，我们介绍了使用沉浸式增强现实 (AR) 遮阳板（特别是 Microsoft HoloLens）来加强对大规模 3D 全息结构的学习的协议和教学方法。我们开发了一种新颖的工作流程，可以在 AR 护目镜中呈现色彩鲜艳的自定义生物分子。此外，我们开发了 AR 练习来回顾与蛋白质或 DNA 结构相关的概念，然后在四个不同的生物学和生物化学课程中实施这些练习。调查显示，学生在练习后对生物分子结构更感兴趣。