N,O-Nucleoside Analogues: Metabolic and Apoptotic Activity.,ChemistryOpen

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N,O-Nucleoside Analogues: Metabolic and Apoptotic Activity.
ChemistryOpen ( IF 2.5 ) Pub Date : 2020-03-24 , DOI: 10.1002/open.202000034
Andrea Marraffa ₁ , Piero Presenti ₁ , Beatrice Macchi ₂ , Francesca Marino-Merlo ₃ , Mariella Mella ₁ , Paolo Quadrelli ₁

Affiliation

Two new families of N,O‐nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.

中文翻译：

N,O-核苷类似物：代谢和细胞凋亡活性。

制备了两个新的N,O核苷类似物家族，其中含有通过亚硝基羰基烯与烯丙醇反应引入的蒽部分。核心结构是异恶唑烷杂环，在 C3 碳上引入苯环或二甲基部分原子。在杂环的5位插入不同的杂碱基。其中一种合成的化合物表现出良好的诱导细胞死亡的能力，并且在处理的细胞中发现了明显的核碎片。

更新日期：2020-03-24

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