The unconventionally selective β-C(sp²)–H activation of enaminones in the presence of various nitrogen nucleophiles, including azoles and cyclic amines, leading to the synthesis of 2-nitrogenated chromones has been achieved by employing a catalytic system consisting of CuI, I₂, PhI(OAc)₂ and Na₂CO₃. The work discloses a new application of functonal enaminones in the synthesis of valuable heterocyclic scaffolds by switching the reaction pathway via unprecedented regioselectivity.

中文翻译：

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铜催化的β-C（sp2）–H N-烯胺酮的杂芳基合成对C2-氮化的色酮

在多种氮亲核试剂（包括吡咯和环胺）的存在下，烯胺酮的非常规选择性β-C（sp ²）–H活化是通过使用由CuI组成的催化体系实现的，从而导致了2-氮代色酮的合成I ₂，PhI（OAc）₂和Na ₂ CO ₃。这项工作揭示了功能性烯胺酮在合成有价值的杂环骨架中的新应用，该合成是通过前所未有的区域选择性来切换反应途径而实现的。