Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(ii) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.

中文翻译：

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用含有全反式维甲酸配体的卡铂类似物打击乳腺癌细胞的转移。

通过点击反应合成了Pt-ATRA，一种含有全反式视黄酸（ATRA）衍生物配体的卡铂类似物。在细胞内化后，Pt-ATRA表现出双重功能，释放活性Pt（ii）部分以诱导细胞凋亡，而ATRA抑制肿瘤转移。