Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy,Chemical Communications

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Gold nanomaterials functionalised with gadolinium chelates and their application in multimodal imaging and therapy
Chemical Communications ( IF 4.3 ) Pub Date : 2020/03/23 , DOI: 10.1039/d0cc00196a
Hannah L. Perry _{1,

2,

3,

4,

5} , René M. Botnar _{5,

6,

7,

8} , James D. E. T. Wilton-Ely _{1,

2,

3,

4,

5}

Affiliation

Over the last decade, much work has been dedicated to improving the performance of gadolinium-based magnetic resonance imaging (MRI) contrast agents by tethering them to biocompatible gold nanoparticles. The enhancement in performance (measured in terms of ‘relaxivity’) stems from the restriction in motion experienced by the gadolinium chelates on being attached to the gold nanoparticle surface. More recently, the unique properties of gold nanoparticles have been exploited to create very promising tools for multimodal imaging and MRI-guided therapies. This review addresses the progress made in the design of gadolinium-functionalised gold nanoparticles for use in MRI, multimodal imaging and theranostics. It also seeks to connect the chemical properties of these assemblies with potential application in the clinic.

中文翻译：

ado螯合物功能化的金纳米材料及其在多峰成像和治疗中的应用

在过去的十年中，通过将them束缚到生物相容性金纳米颗粒上，人们致力于改善based基磁共振成像（MRI）造影剂的性能。性能的增强（用“松弛度”衡量）是由于from螯合物附着在金纳米颗粒表面上而受到的运动限制。最近，金纳米颗粒的独特性质已被利用来创建非常有前途的工具，用于多峰成像和MRI引导疗法。这项审查解决了progress功能化的金纳米颗粒在MRI，多峰成像和治疗学设计中的设计进展。它还试图将这些组件的化学性质与在临床上的潜在应用联系起来。

更新日期：2020-04-09

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