Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have been identified. Several of the recently identified genes encode kinases. In addition, the hypothesis that (de)phosphorylation processes drive the disease process resulting in selective motor neuron degeneration in different disease variants has been postulated. We re-evaluate the evidence for this hypothesis based on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathogenesis. We propose that kinases could represent promising therapeutic targets. Mainly due to the comprehensive regulation of kinases, however, a better understanding of the disturbances in the kinome network in amyotrophic lateral sclerosis is needed to properly target specific kinases in the clinic.

中文翻译：

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激酶在肌萎缩性侧索硬化中的多方面作用：遗传，病理和治疗意义。

肌萎缩性侧索硬化症是成人中最常见的运动神经元变性疾病。由于无法治愈，目前成千上万的人仍然会死于这种疾病。近年来，已经鉴定出许多肌萎缩性侧索硬化的致病基因和危险因素。最近鉴定出的几种基因编码激酶。另外，已经提出了（去）磷酸化过程驱动疾病过程导致不同疾病变体中选择性运动神经元变性的假说。我们基于最近的发现重新评估该假设的证据，并讨论激酶在肌萎缩性侧索硬化病发病机制中的多种作用。我们建议激酶可以代表有希望的治疗靶点。主要是由于激酶的全面调控，