The emerging role of RNA modifications in the regulation of mRNA stability.,Experimental & Molecular Medicine

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The emerging role of RNA modifications in the regulation of mRNA stability.
Experimental & Molecular Medicine ( IF 9.5 ) Pub Date : 2020-03-24 , DOI: 10.1038/s12276-020-0407-z
Sung Ho Boo _{1,

2} , Yoon Ki Kim _{1,

2}

Affiliation

Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs, and the accessibility of various RNA-binding proteins to the mRNAs. Recent advances in high-throughput RNA-sequencing techniques have resulted in the elucidation of the important roles played by mRNA modifications and mRNA nucleotide sequences in regulating mRNA stability. To date, hundreds of different RNA modifications have been characterized. Among them, several RNA modifications, including N6-methyladenosine (m6A), N6,2'-O-dimethyladenosine (m6Am), 8-oxo-7,8-dihydroguanosine (8-oxoG), pseudouridine (Ψ), 5-methylcytidine (m5C), and N4-acetylcytidine (ac4C), have been shown to regulate mRNA stability, consequently affecting diverse cellular and biological processes. In this review, we discuss our current understanding of the molecular mechanisms underlying the regulation of mammalian mRNA stability by various RNA modifications.

中文翻译：

RNA 修饰在 mRNA 稳定性调节中的新作用。

许多研究强调了严格调控 mRNA 稳定性在基因表达控制中的重要性。 mRNA的稳定性很大程度上取决于mRNA的核苷酸序列，其影响mRNA的二级和三级结构，以及各种RNA结合蛋白对mRNA的可及性。高通量 RNA 测序技术的最新进展阐明了 mRNA 修饰和 mRNA 核苷酸序列在调节 mRNA 稳定性中所起的重要作用。迄今为止，数百种不同的 RNA 修饰已被表征。其中，多种RNA修饰，包括N6-甲基腺苷(m6A)、N6,2'-O-二甲基腺苷(m6Am)、8-氧代-7,8-二氢鸟苷(8-oxoG)、假尿苷(Ψ)、5-甲基胞苷(m5C) 和 N4-乙酰胞苷 (ac4C) 已被证明可以调节 mRNA 稳定性，从而影响多种细胞和生物过程。在这篇综述中，我们讨论了目前对通过各种 RNA 修饰调节哺乳动物 mRNA 稳定性的分子机制的理解。

更新日期：2020-04-24

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