Young adulthood body mass index, adult weight gain and breast cancer risk: the PROCAS Study (United Kingdom).,British Journal of Cancer

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Young adulthood body mass index, adult weight gain and breast cancer risk: the PROCAS Study (United Kingdom).
British Journal of Cancer ( IF 6.4 ) Pub Date : 2020-03-23 , DOI: 10.1038/s41416-020-0807-9
Andrew G Renehan _{1,

2} , Mary Pegington _{2,

3} , Michelle N Harvie ₃ , Matthew Sperrin ₄ , Susan M Astley _{5,

6} , Adam R Brentnall ₇ , Anthony Howell _{2,

3} , Jack Cuzick ₇ , D Gareth Evans _{1,

2,

3,

8}

Affiliation

Manchester Cancer Research Centre and NIHR Manchester Biomedical Research Centre, Manchester, UK.
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Prevent Breast Cancer, Nightingale Breast Screening Centre, University Hospital of South Manchester, Manchester, UK.
MRC Health eResearch Centre (HeRC), Division of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Centre for Imaging Science, Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.
The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester, Manchester, UK.
Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester and Central Manchester Foundation Trust, Manchester, UK.

BACKGROUND We tested the hypothesis that body mass index (BMI) aged 20 years modifies the association of adult weight gain and breast cancer risk. METHODS We recruited women (aged 47-73 years) into the PROCAS (Predicting Risk Of Cancer At Screening; Manchester, UK: 2009-2013) Study. In 47,042 women, we determined BMI at baseline and (by recall) at age 20 years, and derived weight changes. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for new breast cancer using Cox models and explored relationships between BMI aged 20 years, subsequent weight changes and breast cancer risk. RESULTS With median follow-up of 5.6 years, 1142 breast cancers (post-menopausal at entry: 829) occurred. Among post-menopausal women at entry, BMI aged 20 years was inversely associated [HR per SD: 0.87 (95% CI: 0.79-0.95)], while absolute weight gain was associated with breast cancer [HR per SD:1.23 (95% CI: 1.14-1.32)]. For post-menopausal women who had a recall BMI aged 20 years <23.4 kg/m2 (75th percentile), absolute weight gain was associated with breast cancer [HR per SD: 1.31 (95% CIs: 1.21-1.42)], but there were no associations for women with a recall BMI aged 20 years of >23.4 kg/m2 (Pinteraction values <0.05). CONCLUSIONS Adult weight gain increased post-menopausal breast cancer risk only among women who were <23.4 kg/m2 aged 20 years.

中文翻译：

青年期体重指数、成人体重增加和乳腺癌风险：PROCAS 研究（英国）。

背景我们测试了这样的假设：20 岁的体重指数 (BMI) 改变了成人体重增加与乳腺癌风险之间的关联。方法我们招募女性（47-73 岁）参与 PROCAS（筛查时预测癌症风险；英国曼彻斯特：2009-2013 年）研究。我们确定了 47,042 名女性的基线体重指数和（通过回忆）20 岁时的体重指数，并得出体重变化。我们使用 Cox 模型估计了新发乳腺癌的风险比 (HR) 和 95% 置信区间 (CI)，并探讨了 20 岁时体重指数、随后的体重变化和乳腺癌风险之间的关系。结果中位随访时间为 5.6 年，共发生 1142 例乳腺癌（入组时绝经后：829 例）。在入组时的绝经后女性中，20 岁的 BMI 呈负相关 [HR/SD: 0.87 (95% CI: 0.79-0.95)]，而绝对体重增加与乳腺癌相关 [HR/SD:1.23 (95% CI) CI：1.14-1.32)]。对于 20 岁时 BMI <23 id=68>23.4 kg/m2 的绝经后女性（Pinteraction 值 <0.05）。结论仅在 20 岁体重<23.4 kg/m2 的女性中，成人体重增加会增加绝经后乳腺癌风险。

更新日期：2020-04-24

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