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Pushing the limit on laminopathies
Nature Materials ( IF 37.2 ) Pub Date : 2020-03-24 , DOI: 10.1038/s41563-020-0648-1
Joel C Eissenberg 1 , Susana Gonzalo 1
Affiliation  

Mutations in lamins in skeletal muscle cells have been shown to reduce nuclear stability, increase nuclear envelope rupture, and induce DNA damage and cell death. New research shows that limiting mechanical loads can rescue myofibre function and viability.

中文翻译:


突破核纤层蛋白病的极限



骨骼肌细胞核纤层蛋白突变已被证明会降低核稳定性,增加核膜破裂,并诱导 DNA 损伤和细胞死亡。新研究表明,限制机械负荷可以挽救肌纤维功能和活力。
更新日期:2020-04-24
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