Microfluidic system, as a kind of miniature integrated operating platform, has been applied to solid-state nanopore sensors after many years of experimental study. In the process of introducing microfluidic into solid-state nanopore sensors, many novel device structures are designed due to the abundance of analytes and the diversity of detection methods. Here we review the fundamental setup of nanopore-based microfluidic systems and the developments and advancements that have been taking place in the field. The microfluidic systems with a multichannel strategy to elevate the throughput and efficiency of nanopore sensors are then presented. Multifunctional detection represented by optical-electrical detection, which is realized by microfluidic integration, is also described. A high integration microfluidic system with nanopore is further discussed, which shows the prototype of commercialization.

中文翻译：

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应用于固态纳米孔传感器的微流控系统

经过多年的实验研究，微流控系统作为一种小型的集成操作平台，已应用于固态纳米孔传感器。在将微流体引入固态纳米孔传感器的过程中，由于分析物的丰富和检测方法的多样性，设计了许多新颖的设备结构。在这里，我们回顾了基于纳米孔的微流体系统的基本设置以及该领域已经发生的发展和进步。然后提出了具有多通道策略以提高纳米孔传感器的通量和效率的微流体系统。还描述了以光电检测为代表的多功能检测，该检测是通过微流体集成实现的。进一步讨论了具有纳米孔的高集成度微流体系统，