The nuclear Dbf2-related (NDR) kinases NDR1 and NDR2 belong to the NDR/LATS (large tumor suppressor) subfamily in the Hippo signaling pathway. They are highly conserved from yeast to humans. It is well-known that NDR1/2 control important cellular processes, such as morphological changes, centrosome duplication, cell proliferation, and apoptosis. Recent studies revealed that NDR1/2 also play important roles in the regulation of infection and inflammation. In this review, we summarized the roles of NDR1/2 in the modulation of inflammation induced by cytokines and innate immune response against the infection of bacteria and viruses, emphasizing on how NDR1/2 regulate signaling transduction through Hippo pathway-dependent and -independent manners.

中文翻译：

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NDR1 / 2在感染和炎症中的新兴作用。

核Dbf2相关（NDR）激酶NDR1和NDR2属于Hippo信号通路中的NDR / LATS（大肿瘤抑制物）亚家族。从酵母到人类，它们都是高度保守的。众所周知，NDR1 / 2控制重要的细胞过程，例如形态变化，中心体复制，细胞增殖和凋亡。最近的研究表明，NDR1 / 2在感染和炎症的调节中也起着重要作用。在这篇综述中，我们总结了NDR1 / 2在调节细胞因子诱导的炎症和抵抗细菌和病毒感染的先天免疫应答中的作用，重点介绍了NDR1 / 2如何通过Hippo途径依赖性和非依赖性方式调节信号转导。 。