Abstract

Understanding of the complicated interactions between biomaterials and cells can accelerate biomedical developments. Recently, many in vitro studies have emphasized the biological features of nanowires (NWs) on the cell’s early response. A type of unique clustered anatase/rutile NWs (ARNWs) was generated using a simple hydrothermal reaction on titanium in the present study. The aim of this study is to determine whether the ARNWs is beneficial for the enhancement of biological capacity. Clustered ARNWs with a diameter of 200 nm were grown on titanium disks via a three-step synthesis process. Three different types of NWs were generated during the production process, displaying different biological characteristics but similar surface topography and wettability. All of the NW surfaces remarkably accelerated the adsorption of albumin protein; however, compared to the ARNWs, a relatively low level of cell attachment and proliferation occurred on the surfaces of sodium titanate NWs (STiNWs) and H₂Ti₂O₅ nanowires (HTiNWs). The data indicated that the surface titanium oxide crystal structure plays an important role in the cell’s early response. To some extent, the generation of anatase and rutile of the ARNWs compensated for the cell-repelling properties. The crystal structure and potential larger loading capacity of the ARNWs face challenges for enhanced cellular adaptation which could improve its clinical potential.

中文翻译：

---

簇状锐钛矿/金红石纳米线阵列修饰的钛表面的结构和生物学特性

摘要

了解生物材料与细胞之间复杂的相互作用可以加速生物医学的发展。最近，许多体外研究都强调了纳米线（NWs）在细胞早期反应中的生物学特性。在本研究中，使用钛上的简单水热反应生成了一种独特的簇状锐钛矿/金红石型净水（ARNW）。这项研究的目的是确定ARNW是否有利于增强生物能力。直径为200 nm的成簇的ARNW通过三步合成工艺在钛圆片上生长。在生产过程中生成了三种不同类型的净水，它们具有不同的生物学特性，但具有相似的表面形貌和润湿性。NW的所有表面均显着加速了白蛋白的吸附。然而，₂ Ti ₂ O ₅纳米线（HTiNWs）。数据表明，表面氧化钛晶体结构在电池的早期反应中起重要作用。在某种程度上，ARNW的锐钛矿和金红石的产生补偿了细胞排斥特性。ARNW的晶体结构和潜在的更大负载能力面临着增强细胞适应性的挑战，这可能会改善其临床潜力。