We first demonstrate a simple and rapid fabrication protocol of bovine serum albumin (BSA) nanoparticles (NPs), as potential drug carriers using a microchannel flow technique with the successful encapsulation of a water-soluble kynurenic acid (KYNA) having neuroactive property has also been performed. By comparison, the preparation of a hydrophobic α-Tocopherol (TP)-loaded polylactide-co-glycolide 50:50 (PLGA50)-based NPs was also carried out under flow conditions. We highlight several benefits of the flow technique over the commonly known self-assembly and nanoprecipitation processes. The average particle diameter, the size distribution, the encapsulation efficiency (EE%) and the drug release kinetics of these different core-shell type NPs prepared by the flow as well as the above-mentioned classic methods were compared. The decisive role of the flow rate (FR), the relative flow rate (RFR) of the components in the particle size of both BSA- and PLGA50-based NPs have also been verified. By utilization of the optimal flow conditions, the average size can be decreased with ca. 15–20% and lower polydispersity index (PDI) can be also achieved. It was confirmed that the systematic change of the RFR values resulting in the controlled size of the drug-loaded BSA NPs between 120 and 140 nm, while d = 149 nm was obtained for self-assembled NPs. However, for BSA-based NPs quite similar EE% was obtained for both methods (ca. 11–12%), but for PLGA50/TP NPs the application of flow device increased the EE% from 67.0% to 71.5%.

我们首先展示了一种简单而快速的牛血清白蛋白（BSA）纳米颗粒（NPs）的制备方案，它是使用微通道流动技术成功封装具有神经活性的水溶性犬尿酸（KYNA）的潜在药物载体。执行。相比之下，疏水性α生育酚（TP）的制备聚交酯-loaded共还在流动条件下进行了基于乙交酯50:50（PLGA50）的NP。我们着重介绍了流动技术相对于众所周知的自组装和纳米沉淀工艺的几个优点。比较了用流动法以及上述经典方法制备的这些不同核-壳型NP的平均粒径，尺寸分布，包封效率（EE％）和药物释放动力学。流速（FR），组分的相对流速（RFR）在基于BSA和PLGA50的NP粒径中的决定性作用也已得到验证。通过利用最佳流动条件，平均尺寸可以减小约。也可以达到15–20％，并且较低的多分散指数（PDI）。可以确认，RFR值的系统变化导致载药BSA NP的尺寸控制在120至140 nm之间，而自组装NP的d = 149 nm。但是，对于基于BSA的NP，两种方法均获得了相当的EE％（约11–12％），但是对于PLGA50 / TP NP，使用流量装置将EE％从67.0％提高到71.5％。