Eight new alkaloids, including five isoquinoline alkaloids, a benzoazepine alkaloid, two isoindole alkaloids, and three synthetic alkaloids firstly obtained from the natural sources, together with three known ones were isolated from the bulbs of Corydalis decumbens. The structures were determined by analysis of their spectroscopic data and single-crystal X-ray diffraction. This is the first report of isoindole alkaloid and benzoazepine alkaloid from the genus Corydalis. Full NMR data for 9-11 are reported here for the first time. Moreover, the ability to modulate neuronal Ca2+ mobilization of the isolated alkaloids was tested in primary cultured neocortical neurons. Compound 7 inhibited spontaneous Ca2+ oscillations in primary neocortical neuron cultures at low micromolar concentrations.

中文翻译：

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延胡索中的生物碱调节神经元兴奋性。

从延胡索鳞茎中分离到了8种新生物碱，其中包括5种异喹啉类生物碱，苯并氮杂烷生物碱，2种异吲哚生物碱和3种合成生物碱。通过分析其光谱数据和单晶X射线衍射确定结构。这是紫堇属中的异吲哚生物碱和苯并氮杂生物碱的首次报道。首次报告9-11的完整NMR数据。此外，在原代培养的新皮层神经元中测试了调节分离的生物碱的神经元Ca2 +动员的能力。在低微摩尔浓度下，化合物7抑制了新皮层神经元原代培养物中的自发Ca2 +振荡。