Systematic and comprehensive methodologies for the analysis of toxic metals in the environment and living organisms are required to bridge a great knowledge gap between metal exposure and related ecological risks or adverse health effects. In this review, the concepts of “environmetallomics” and the “environmetallome” are explicitly defined, which was distinctly differentiated from “an environmental branch in traditional metallomics”. Based on these concepts, this article summarizes and discusses the current research progress and perspectives on analytical approaches and technologies of the metals, which have shown promise in environmetallomics studies. Aspects discussed include the bioavailability, concentrations, speciation and distribution mapping of toxic metals in the ecosphere and even at the cellular and subcellular levels, as well as metal interactions with proteomes and genomes in terms of metalloprotein profiling and bioinformatics analysis. The use and development of systematic, comprehensive and global methodologies in environmetallomics, would enable us to address the key issues of metal pollution in environmental health and toxicology.

需要系统和综合的方法来分析环境和生物中的有毒金属，以弥合金属暴露与相关生态风险或不利健康影响之间的巨大知识鸿沟。在这次审查中，“概念environmetallomics ”和“ environmetallome明确定义”，这与“传统冶金学中的环境分支”明显不同。基于这些概念，本文总结并讨论了金属的分析方法和技术的最新研究进展和观点，这些都在环境金属学研究中显示出了希望。讨论的方面包括生态圈甚至在细胞和亚细胞水平上有毒金属的生物利用度，浓度，形态和分布图，以及在金属蛋白谱分析和生物信息学分析方面与蛋白质组和基因组的金属相互作用。在环境金属学中使用和开发系统，全面和全球性的方法论将使我们能够解决环境健康和毒理学中金属污染的关键问题。