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COVID-19: Melatonin as a potential adjuvant treatment.
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-23 , DOI: 10.1016/j.lfs.2020.117583 Rui Zhang 1 , Xuebin Wang 1 , Leng Ni 1 , Xiao Di 1 , Baitao Ma 1 , Shuai Niu 1 , Changwei Liu 1 , Russel J Reiter 2
Life Sciences ( IF 5.2 ) Pub Date : 2020-03-23 , DOI: 10.1016/j.lfs.2020.117583 Rui Zhang 1 , Xuebin Wang 1 , Leng Ni 1 , Xiao Di 1 , Baitao Ma 1 , Shuai Niu 1 , Changwei Liu 1 , Russel J Reiter 2
Affiliation
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This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.
中文翻译：
COVID-19：褪黑激素作为潜在的辅助治疗。
本文根据其假定的发病机制总结了褪黑激素在减弱 COVID-19 方面的可能益处。最近爆发的新型冠状病毒肺炎 (COVID-19) 已成为一种大流行病，有数万名感染者。根据高度同质性冠状病毒或其他病原体引起的急性呼吸系统疾病的临床特征、病理学和发病机制，证据表明过度炎症、氧化和过度的免疫反应很可能导致 COVID-19 病理学。这会导致细胞因子风暴，并随后进展为急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS），甚至死亡。褪黑激素是一种众所周知的抗炎和抗氧化分子，可预防病毒和其他病原体引起的 ALI/ARDS。褪黑素通过减少血管通透性、焦虑、镇静剂使用和改善睡眠质量，对重症监护患者有效，这也可能有利于 COVID-19 患者获得更好的临床结果。值得注意的是，褪黑激素具有很高的安全性。有重要数据表明，褪黑激素可以限制与病毒相关的疾病，并且也可能对 COVID-19 患者有益。需要更多的实验和临床研究来证实这一推测。
更新日期：2020-03-24
中文翻译：
COVID-19：褪黑激素作为潜在的辅助治疗。
本文根据其假定的发病机制总结了褪黑激素在减弱 COVID-19 方面的可能益处。最近爆发的新型冠状病毒肺炎 (COVID-19) 已成为一种大流行病，有数万名感染者。根据高度同质性冠状病毒或其他病原体引起的急性呼吸系统疾病的临床特征、病理学和发病机制，证据表明过度炎症、氧化和过度的免疫反应很可能导致 COVID-19 病理学。这会导致细胞因子风暴，并随后进展为急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS），甚至死亡。褪黑激素是一种众所周知的抗炎和抗氧化分子，可预防病毒和其他病原体引起的 ALI/ARDS。褪黑素通过减少血管通透性、焦虑、镇静剂使用和改善睡眠质量，对重症监护患者有效，这也可能有利于 COVID-19 患者获得更好的临床结果。值得注意的是，褪黑激素具有很高的安全性。有重要数据表明，褪黑激素可以限制与病毒相关的疾病，并且也可能对 COVID-19 患者有益。需要更多的实验和临床研究来证实这一推测。
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