In this work, we describe the design of a novel combination (chemo-photothermal) therapeutic model comprising vincristine (VCR) as phytochemical anticancer and plasmonic gold nanorods (GNRs) for laser-induced photothermal ablation of tumor. VCR was loaded in an amphiphilic PLGA-PEG polymeric corona covalently assembled around silica coated GNRs. The acid sensitive amide linkage conferred a VCR sustained release profile in the cancer acidic microenvironment. In vitro studies showed the high stability of the multilayer nanoprobes in the physiological medium (pH 7.4) versus a sustained release profile of VCR in stimulated cancer microenvironment (pH = 5.0). Treatment of golden hamster with chemically-induced oral squamous carcinoma (OSCC) with the proposed nanoformulations revealed superior anticancer efficacy in terms of reduced mortality rates, tumor regression and dramatic histopathological changes of the cancer cells within the therapeutic course.

在这项工作中，我们描述了包含长春新碱（VCR）作为植物化学抗癌剂和等离激元金纳米棒（GNR）的新型组合（化学光热）治疗模型的设计，用于激光诱导的肿瘤光热消融。将VCR装入共价组装在二氧化硅涂层的GNR周围的两亲PLGA-PEG聚合物电晕中。酸敏感性酰胺键在癌症酸性微环境中赋予了VCR持续释放特性。体外研究表明，多层纳米探针在生理介质（pH 7.4）中具有很高的稳定性，而在受刺激的癌症微环境（pH = 5.0）中，VCR的缓释特性却很高。拟议的纳米制剂用化学诱导的口腔鳞状细胞癌（OSCC）治疗金黄仓鼠显示出降低死亡率的优异抗癌功效，