Pioneer transcription factors are a recently defined class of transcription factors which can bind directly to nucleosomal DNA; they play a key role in gene activation in certain pathways. Here we quantify their role in the initiation of nucleosome displacement within the kinetic proofreading scenario of chromatin remodeling. The model allows to perform remodeling efficiency comparisons for scenarios involving different types of transcription factors and remodelers as a function of their binding and unbinding rates and concentrations. Our results demonstrate a novel way to fine-tune the specificity of processes that modify the chromatin structure in transcriptional initiation.

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染色质重塑中的先锋转录因子：动力学校对视图

先锋转录因子是最近定义的一类转录因子，可以直接结合核小体DNA。它们在某些途径的基因激活中起关键作用。在这里我们量化他们在染色质重塑的动力学校对情况下核小体置换的启动中的作用。该模型允许针对涉及不同类型的转录因子和重塑剂的场景进行重塑效率比较，这取决于它们的结合和解离速率以及浓度。我们的结果证明了一种新颖的方法，可以微调在转录起始过程中修饰染色质结构的过程的特异性。