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Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases.
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2020-03-23 , DOI: 10.1021/acs.chemrestox.0c00010
Klaudia Chmielewska 1 , Krystyna Dzierzbicka 1 , Iwona Inkielewicz-Stępniak 2 , Maja Przybyłowska 1
Affiliation  

Despite significant progress in the pathogenesis, diagnosis, treatment, and prevention of cancer and neurodegenerative diseases, their occurrence and mortality are still high around the world. The resistance of cancer cells to the drugs remains a significant problem in oncology today, while in the case of neuro-degenerative diseases, therapies reversing the process are still yet to be found. Furthermore, it is important to seek new chemotherapeutics reversing side effects of currently used drugs or helping them perform their function to inhibit progression of the disease. Carnosine, a dipeptide constisting of β-alanine and l-histidine, has a variety of functions to mention: antioxidant, antiglycation, and reducing the toxicity of metal ions. It has therefore been proposed to act as a therapeutic agent for many pathological states. The aim of this paper was to find if carnosine and its derivatives can be helpful in treating various diseases. Literature search presented in this review includes review and original papers found in SciFinder, PubMed, and Google Scholar. Searches were based on substantial keywords concerning therapeutic usage of carnosine and its derivatives in several diseases including neurodegenerative disorders and cancer. In this paper, we review articles and find that carnosine and its derivatives are potential therapeutic agents in many diseases including cancer, neurodegenerative diseases, diabetes, and schizophrenia. Carnosine and its derivatives can be used in treating neurodegenerative diseases, cancer, diabetes, or schizophrenia, although their usage is limited. Therefore, there’s an urge to synthesize and analyze new substances, overcoming the limitation of carnosine itself.

中文翻译:

肌肽及其衍生物在人类疾病治疗中的治疗潜力。

尽管在癌症和神经退行性疾病的发病机理,诊断,治疗和预防方面取得了重大进展,但在世界范围内,它们的发生率和死亡率仍然很高。当今,肿瘤细胞对癌细胞的抗药性仍然是一个重大问题,而在神经退行性疾病的情况下,尚未找到逆转这一过程的疗法。此外,重要的是寻找新的化学疗法以逆转当前使用的药物的副作用或帮助它们发挥其抑制疾病进展的功能。肌肽,由β-丙氨酸和l组成的二肽-组氨酸,具有多种功能:抗氧化剂,抗糖基化作用和降低金属离子的毒性。因此,已经提出将其用作许多病理状态的治疗剂。本文的目的是发现肌肽及其衍生物是否可以帮助治疗各种疾病。这篇评论中提出的文献检索包括评论和在SciFinder,PubMed和Google Scholar中找到的原始论文。搜索基于关于肌肽及其衍生物在包括神经退行性疾病和癌症在内的几种疾病中的治疗用途的重要关键词。在本文中,我们对文章进行了审查,发现肌肽及其衍生物是许多疾病(包括癌症,神经退行性疾病,糖尿病和精神分裂症)的潜在治疗剂。肌肽及其衍生物可用于治疗神经退行性疾病,癌症,糖尿病或精神分裂症,尽管其使用受到限制。因此,迫切需要合成和分析新物质,以克服肌肽本身的局限性。
更新日期:2020-03-23
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