Vibrio cholerae (V. cholerae) uses the autoinducer CAI-1 (cholera autoinducer 1) and several linked quorum sensing systems in order to efficiently sense its ever-changing environment and optimally coordinate population-wide gene expression. Indole has been reported as an important signal that is sensed by V. cholerae, and here, we report the synthesis and evaluation of a focused library of synthetic indole-CAI-1 derivatives as tools to probe quorum sensing (QS) in this human pathogen. Our results show interesting and diverging effects for several conjugates, as compared to CAI-1, on virulence factor production and biofilm formation.

中文翻译：

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霍乱弧菌群体感应的基于吲哚的自体诱导剂的合成和评价。

霍乱弧菌（霍乱弧菌）使用自动诱导物CAI-1（霍乱自动诱导物1）和几个链接的群体感应系统，以便有效地感应其不断变化的环境并优化协调整个人群的基因表达。吲哚已被报告为霍乱弧菌感测的重要信号，在这里，我们报道了合成吲哚-CAI-1衍生物的重点文库的合成和评估，该文库可作为探测该人类病原体中群体感应（QS）的工具。我们的结果显示，与CAI-1相比，几种缀合物对毒力因子产生和生物膜形成的有趣且不同的影响。