当前位置：
X-MOL 学术
›
ACS Biomater. Sci. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Photothermal Polymerization Using Graphene Oxide for Robust Hydrogelation with Various Light Sources
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-03-23 , DOI: 10.1021/acsbiomaterials.0c00161 Hwangjae Lee 1 , Semin Kim 1 , Chiseon Ryu 1 , Jae Young Lee 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-03-23 , DOI: 10.1021/acsbiomaterials.0c00161 Hwangjae Lee 1 , Semin Kim 1 , Chiseon Ryu 1 , Jae Young Lee 1
Affiliation
|
Photopolymerization has been widely used for remote inducible hydrogelation with excellent spatiotemporal control. Recently, photothermal hydrogelation using near-infrared (NIR) light and photothermal agents has been developed showing remote hydrogelation ability with good biocompatibility and tissue penetration. However, the use of plasmonic nanoparticles (e.g., gold nanorods (GNRs)) still causes problems in reaction efficiency because hydrogelation is effective only when the wavelength of light is matched with the optical properties of the GNRs. Here, we demonstrated wavelength-independent photothermal hydrogelation using PEGylated graphene oxide (GO-PEG) that displays excellent heat generation from lights of a wide range of wavelengths. A sufficient increase in the temperature of the GO-PEG solution and the induction of thermal gelation of polyethylene diacrylate (PEGDA) by irradiation of various light sources (532, 785, and 980 nm) were demonstrated. Also, the GO-PEG-based photothermal hydrogelation of PEGDA was successfully employed for remote transdermal gel formation in vivo with 785 and 980 nm lasers. This wavelength-independent photothermal hydrogelation system will be useful for biomedical applications.
中文翻译：
使用氧化石墨烯进行光热聚合以在各种光源下进行稳健的水凝胶化
光聚合已被广泛用于具有出色的时空控制的远程诱导水凝胶化。近来，已经开发出使用近红外（NIR）光和光热剂的光热水凝胶化，其显示出远距离水凝胶化能力以及良好的生物相容性和组织渗透性。然而，等离子纳米颗粒（例如金纳米棒（GNR））的使用仍然引起反应效率方面的问题，因为仅当光的波长与GNR的光学性质匹配时，水凝胶化才有效。在这里，我们展示了使用聚乙二醇化氧化石墨烯（GO-PEG）的与波长无关的光热凝胶化，该凝胶显示出从各种波长的光产生的出色热量。结果表明，通过各种光源（532、785和980 nm）的照射，GO-PEG溶液的温度充分升高，并引发了聚二丙烯酸乙二醇酯（PEGDA）的热凝胶化。而且，基于PEGDA的基于GO-PEG的光热水凝胶化已成功用于785和980 nm激光在体内的远程透皮凝胶形成。这种与波长无关的光热凝胶化系统将对生物医学应用有用。
更新日期：2020-04-23
中文翻译：
使用氧化石墨烯进行光热聚合以在各种光源下进行稳健的水凝胶化
光聚合已被广泛用于具有出色的时空控制的远程诱导水凝胶化。近来，已经开发出使用近红外（NIR）光和光热剂的光热水凝胶化，其显示出远距离水凝胶化能力以及良好的生物相容性和组织渗透性。然而，等离子纳米颗粒（例如金纳米棒（GNR））的使用仍然引起反应效率方面的问题，因为仅当光的波长与GNR的光学性质匹配时，水凝胶化才有效。在这里，我们展示了使用聚乙二醇化氧化石墨烯（GO-PEG）的与波长无关的光热凝胶化，该凝胶显示出从各种波长的光产生的出色热量。结果表明，通过各种光源（532、785和980 nm）的照射，GO-PEG溶液的温度充分升高，并引发了聚二丙烯酸乙二醇酯（PEGDA）的热凝胶化。而且，基于PEGDA的基于GO-PEG的光热水凝胶化已成功用于785和980 nm激光在体内的远程透皮凝胶形成。这种与波长无关的光热凝胶化系统将对生物医学应用有用。
京公网安备 11010802027423号