Photothermal therapy (PTT) is an effective treatment modality with high selectivity for tumor suppression. However, the inflammatory responses caused by PTT may lead to adverse reactions including tumor recurrence and therapeutic resistance, which are regarded as major problems for PTT. Here, a near-infrared (NIR) light-responsive nanoreactor (P@DW/BC) is fabricated to simultaneously realize tumor PTT and carbon monoxide (CO)-mediated anti-inflammatory therapy. Defective tungsten oxide (WO₃) nanosheets (DW NSs) are decorated with bicarbonate (BC) via ferric ion-mediated coordination and then modified with polyethylene glycol (PEG) on the surface to fabricate PEG@DW/BC or P@DW/BC nanosheets. Upon 808 nm NIR laser irradiation, the DW content in P@DW/BC can serve as not only a photothermal agent to realize photothermal conversion but also a photocatalyst to convert carbon dioxide (CO₂) to CO. In particular, the generated heat can also trigger the decomposition of BC to produce CO₂ near the NSs, thus enhancing the photocatalytic CO generation. Benefiting from the efficient hyperthermia and CO generation under single NIR laser irradiation, P@DW/BC can realize effective thermal ablation of tumor and simultaneous inhibition of PTT-induced inflammation.

中文翻译：

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同时进行肿瘤光热疗法和一氧化碳介导的抗炎的近红外响应纳米反应器。

光热疗法（PTT）是一种有效的治疗方式，对肿瘤抑制具有高选择性。然而，由PTT引起的炎性反应可能导致包括肿瘤复发和治疗抗性在内的不良反应，这被认为是PTT的主要问题。在这里，制造了一个近红外（NIR）光响应纳米反应器（P @ DW / BC），以同时实现肿瘤PTT和一氧化碳（CO）介导的抗炎治疗。氧化钨不良（WO ₃纳米片（DW NSs）通过三价铁离子介导的配位用碳酸氢盐（BC）装饰，然后在表面上用聚乙二醇（PEG）修饰以制造PEG @ DW / BC或P @ DW / BC纳米片。在808 nm NIR激光照射下，P @ DW / BC中的DW含量不仅可以用作实现光热转化的光热剂，而且还可以用作将二氧化碳（CO ₂）转化为CO的光催化剂。特别是，产生的热量可以还触发了BC的分解，在NSs附近产生CO ₂，从而增强了光催化CO的产生。P @ DW / BC得益于在单个NIR激光照射下高效的热疗和CO生成，可以实现肿瘤的有效热消融并同时抑制PTT诱导的炎症。