Thermoresponsive Block Copolymer Vesicles by Visible Light-Initiated Seeded Polymerization-Induced Self-Assembly for Temperature-Regulated Enzymatic Nanoreactors,ACS Macro Letters

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Thermoresponsive Block Copolymer Vesicles by Visible Light-Initiated Seeded Polymerization-Induced Self-Assembly for Temperature-Regulated Enzymatic Nanoreactors
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-03-23 , DOI: 10.1021/acsmacrolett.0c00151
Jun He ₁ , Junpeng Cao ₁ , Ying Chen ₂ , Li Zhang _{1,

2} , Jianbo Tan _{1,

2}

Affiliation

Block copolymer vesicles loaded with active compounds have been employed as decent candidates to mimic complex biological systems that attract considerable interest in different research communities. We herein report a visible light-initiated seeded reversible addition–fragmentation chain transfer (RAFT)-mediated polymerization-induced self-assembly (PISA) for in situ preparation of enzyme-loaded cross-linked block copolymer vesicles without compromising the bioactivity. Permeability of the vesicular membrane can be regulated through changing the solution temperature, allowing further control over the enzymatic reaction rate of enzyme-loaded vesicles. Finally, non-cross-linked thermoresponsive block copolymer vesicles that can transform into worm-like micelles at low temperature are also prepared by this method, allowing the release of bimacromolecules from the vesicles under mild conditions.

中文翻译：

用于温度调节酶纳米反应器的可见光引发种子聚合诱导自组装的热响应嵌段共聚物囊泡

负载有活性化合物的嵌段共聚物囊泡已被用作模拟复杂生物系统的合适候选者，这些系统在不同的研究界引起了极大的兴趣。我们在此报道了一种可见光引发的种子可逆加成-断裂链转移（RAFT）介导的聚合诱导自组装（PISA），用于在不影响生物活性的情况下原位制备载酶交联嵌段共聚物囊泡。囊泡膜的渗透性可以通过改变溶液温度来调节，从而进一步控制载酶囊泡的酶促反应速率。最后，该方法还制备了可在低温下转变为蠕虫状胶束的非交联热响应性嵌段共聚物囊泡，

更新日期：2020-04-23

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