当前位置：
X-MOL 学术
›
J. Phys. Chem. B
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Incorporating a Tetrapeptide into Lyotropic Direct Hexagonal Mesophase
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2020-03-24 , DOI: 10.1021/acs.jpcb.0c00512 Natalia M. Selivanova 1 , Aidar T. Gubaidullin 2 , Yuriy G. Galyametdinov 1
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2020-03-24 , DOI: 10.1021/acs.jpcb.0c00512 Natalia M. Selivanova 1 , Aidar T. Gubaidullin 2 , Yuriy G. Galyametdinov 1
Affiliation
|
An approach to incorporate a bioactive hydrophobic substance, C22H32N4O7 tetrapeptide (TP), into the structure of the hexagonal mesophases C12EO10/H2O and C12EO10/La(III)/H2O was proposed. Concentration and temperature ranges of mesophases in the C12EO10/H2O/TP and C12EO10/La(III)/H2O/TP systems were established. The analysis of the X-ray diffraction data revealed a change in the structural characteristics of mesophases in the presence of tetrapeptide. Formation of a denser packing of molecules in the mesophases with TP was detected. Based on the FTIR spectroscopy data, intermolecular changes in the systems were examined. Pulsed-gradient spin–echo NMR self-diffusion experiments were performed to characterize the structure of lyomesophases depending on system composition and temperature. The degree of hydration of water molecules in lyomesophases was analyzed. The data confirmed successful incorporation of tetrapeptide into the structure of lyomesophase and, therefore, the possibility of using hexagonal mesophases for both incapsulation and delivery of biomolecules.
中文翻译：
将四肽掺入溶致的直接六方中间相中
一种将生物活性疏水物质C 22 H 32 N 4 O 7四肽（TP）掺入六方中间相C 12 EO 10 / H 2 O和C 12 EO 10 / La（III）/ H 2的结构中的方法提出了O。C 12 EO 10 / H 2 O / TP和C 12 EO 10 / La（III）/ H 2中中间相的浓度和温度范围建立了O / TP系统。X射线衍射数据的分析揭示了在四肽存在下中间相的结构特征的变化。检测到在中间相中与TP形成了更密集的分子堆积。根据FTIR光谱数据，检查了系统中的分子间变化。进行了脉冲梯度自旋回波NMR自扩散实验，以根据系统组成和温度表征溶血相的结构。分析了溶酶期中水分子的水合程度。数据证实四肽成功地掺入到溶血相的结构中，因此，有可能使用六角形的中间相用于生物分子的包封和递送。
更新日期：2020-03-24
中文翻译：
将四肽掺入溶致的直接六方中间相中
一种将生物活性疏水物质C 22 H 32 N 4 O 7四肽（TP）掺入六方中间相C 12 EO 10 / H 2 O和C 12 EO 10 / La（III）/ H 2的结构中的方法提出了O。C 12 EO 10 / H 2 O / TP和C 12 EO 10 / La（III）/ H 2中中间相的浓度和温度范围建立了O / TP系统。X射线衍射数据的分析揭示了在四肽存在下中间相的结构特征的变化。检测到在中间相中与TP形成了更密集的分子堆积。根据FTIR光谱数据，检查了系统中的分子间变化。进行了脉冲梯度自旋回波NMR自扩散实验，以根据系统组成和温度表征溶血相的结构。分析了溶酶期中水分子的水合程度。数据证实四肽成功地掺入到溶血相的结构中，因此，有可能使用六角形的中间相用于生物分子的包封和递送。
京公网安备 11010802027423号