Access to Phenothiazine Derivatives via Iodide-Mediated Oxidative Three-Component Annulation Reaction,The Journal of Organic Chemistry

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Access to Phenothiazine Derivatives via Iodide-Mediated Oxidative Three-Component Annulation Reaction
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-03-23 , DOI: 10.1021/acs.joc.0c00562
Qinghua Chen ₁ , Rong Xie ₁ , Huanhuan Jia ₁ , Jialu Sun ₁ , Guangpeng Lu ₁ , Huanfeng Jiang ₁ , Min Zhang ₁

Affiliation

Herein, a new iodide-mediated three-component annulation reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chemical bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chemistry capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.

中文翻译：

通过碘化物介导的氧化三组分环化反应获得吩噻嗪衍生物

本文展示了一种新的碘化物介导的仲苯胺，环己酮和元素硫的三组分环化反应，该反应可通过一次操作即可形成多个化学键，步骤效率高和原子效率高的特点，从而获得各种吩噻嗪类化合物，容易获得的原料和催化剂体系，以及良好的底物和官能团相容性。能够构建具有结构多样性的新型吩噻嗪的已开发化学方法为进一步应用提供了重要基础。

更新日期：2020-04-24

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