Breast cancer has the highest incidence and mortality in the female population. Forkhead box M1 (FOXM1) known as a transcription factor is upregulated and associated with poor prognosis in a variety of cancers. However, the molecular mechanisms of FOXM1 on breast cancer progression are poorly understood. In this study, we found that FOXM1 was up-regulated in breast cancer. FOXM1 promoted cell proliferation, clonal formation, and migration capacity in triple negative breast cancer by increasing transcriptional activity of YAP1. FOXM1 also maintained cell stemness via the Hippo pathway. The YAP1-TEAD binding inhibitor Verteporfin reduced the transcription level of OCT4 and NANOG but the Hippo pathway activator XMU-MP-1 could increase the transcription level of OCT4 and NANOG. In summary, our findings indicated that FOXM1 promoted breast cancer progression through the Hippo pathway, and it was suggested a new strategy to treat breast cancer.

中文翻译：

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FOXM1以依赖YAP1的方式促进乳腺癌细胞的干性和迁移。

乳腺癌在女性人群中发病率和死亡率最高。被称为转录因子的叉头盒M1（FOXM1）被上调，并与多种癌症的不良预后相关。然而，FOXM1对乳腺癌进展的分子机制了解甚少。在这项研究中，我们发现FOXM1在乳腺癌中被上调。FOXM1通过增加YAP1的转录活性来促进三阴性乳腺癌中的细胞增殖，克隆形成和迁移能力。FOXM1还通过Hippo途径维持细胞干性。YAP1-TEAD结合抑制剂Verteporfin降低了OCT4和NANOG的转录水平，但是Hippo通路激活剂XMU-MP-1可以增加OCT4和NANOG的转录水平。综上所述，