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Prospecting alternative source of shikimic acid from clusiaceae of Western Ghats, India and evaluating discrepancies with reference to seasonal variation, developmental stage and sex of Mammea suriga
Industrial Crops and Products ( IF 5.9 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.indcrop.2020.112354
Parthraj R. Kshirsagar , Sandeep R. Pai , Govind D. Vyavahare , Vishwas A. Bapat , Neetin S. Desai

Clusiaceae is renowned for producing a wide range of phytochemicals like isoprenylated xanthones, biflavonoids and anthraquinones. Recently, focus on Shikimic Acid (SA) has increased since its appearance as a key precursor for the synthesis of drug against H5N1 virus. Present work quantifies shikimic acid from, different parts of clusiaceae species. RP-HPLC analysis showed M. suriga collected form Siddhapur with higher content of shikimic acid (47.19 mg/g). Similarly, leaves of all species showed highest content of SA than stem and fruits of species analyzed. Results revealed that the seasons had important role in accumulation of SA in M. suriga. While, young leaves showed highest accumulation of SA compared to old and different growth stages and sexuality of M. suriga does not affect SA content. Similarly, various method had less role in extraction of SA. The present investigation is the first comprehensive report on clusiaceae species with respect to shikimic acid and the findings are of considerable interest to design new bioproducts in pharmaceutical point of view and to provide suitable alternative source of SA to star anise.



中文翻译:

从印度西高止山脉的clusiaceae中寻找sh草酸的替代来源,并根据季节性变种,发育阶段和苏门氏菌的性别评估差异

伞形科因生产多种植物化学物质而闻名,例如异戊二烯化的氧杂蒽酮,双fl类生物体和蒽醌。近来,由于Shikimic Acid(SA)成为抗H5N1病毒药物合成的关键前体,因此对它的关注日益增加。目前的工作是对桔梗科不同部位的sh草酸进行定量分析。RP-HPLC分析表明,从悉达浦(Siddhapur)收集的苏氏沼虾具有较高的sh草酸含量(47.19 mg / g)。同样,所有物种的叶片中SA含量均高于所分析物种的茎和果实。结果表明,季节对suriga分支杆菌SA的积累具有重要作用。同时,与旧的和不同的生长期和M. suriga的有性相比,幼叶表现出最高的SA积累不影响SA含量。同样,各种方法在提取SA中的作用较小。本研究是关于cl草科物种sh草酸的第一份综合报告,发现对于从制药学角度设计新的生物产品并为八角茴香提供合适的SA替代来源具有重大意义。

更新日期:2020-03-22
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