INTRODUCTION Endocrine dysregulation's role in heterotopic ossification (HO) remains unexplored. We sought to examine corticosterone and testosterone in established rat models of ectopic bone formation, and correlate to HO formation with CT analysis. METHODS Fifteen rats were placed into three groups of traumatic injury patterns: Blast and injury (120 kPa blast, femoral fracture and quadriceps crush), injury only, and blast only. Serum corticosterone and testosterone levels were drawn until post-operative day 40. HO was analyzed using CT. RESULTS Corticosterone levels peaked in the blast and injury group in the shortest time post injury, followed by injury only and blast only groups. Testosterone levels reached nadir in similar fashion. Volume of HO was highest in the blast and injury group, followed by the injury only group. CONCLUSION Corticosterone and testosterone's contribution to HO formation requires further characterization, but this study suggests that high peaks in corticosterone and a low nadir in testosterone are associated with higher volumes of HO.

中文翻译：

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爆炸和截肢大鼠异位骨化模型中睾丸激素和皮质酮血清水平的表征。

引言内分泌失调在异位骨化（HO）中的作用尚待探索。我们试图检查已建立的异位骨形成大鼠模型中的皮质酮和睾丸激素，并与CT分析与HO形成相关。方法将15只大鼠分为三组创伤伤害类型：爆炸和伤害（120 kPa爆炸，股骨骨折和股四头肌挤压），仅伤害和仅爆炸。抽取血清皮质激素和睾丸激素水平直至术后第40天。使用CT分析HO。结果在爆炸后最短的时间内，冲击波和伤害组中的皮质酮水平达到峰值，随后是仅伤害和仅冲击波组。睾丸激素水平以类似的方式达到最低点。爆炸和伤害组的HO量最高，其次是仅伤害组。